Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
Most Useful Reviews
8.8
Overall wellbeing
The benefits of calcium and magnesium for health are immense! They ensure proper brain function, strengthen bones, improve sleep quality, lower blood pressure, and support the nervous system among others. I've noticed improvements in my teeth and nails, as well as a decrease in impulsive behaviour, leading to greater calmness in various situations. This dietary supplement truly works! In comparison with others, it offers an excellent price-to-quality ratio and suitable dosages. I wish everyone good health and longevity!
6.8
Cognitive clarity
This supplement has significantly improved my PMDD! It's a fantastic deal, providing many pills for a reasonable price. It has enhanced my sleep and reduced the brain fog I experience during my luteal phase, a time when studies suggest calcium levels are lower.
9
Mood enhancement
I found that it keeps my nervous system in order while also benefiting my nails and bones during breastfeeding. This issue had been with me for about a year, but I finally decided to take action when my daughter was six months old. After four months of use, I've objectively seen improvements. My leg cramps, often caused by a calcium-magnesium deficiency, vanished after the first month. Despite spending nine months at home with my child—known to be a challenging time—my nerves remain calm. I believe this is largely due to the support from the supplement. I've not experienced any issues with my teeth or nails, which many nursing mothers encounter. I attribute this to the benefits of the supplement.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.6
- All Researches
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
8
We explored how magnesium sulfide nanoparticles (MgS NPs) affect the SH-SY5Y neuroblastoma cell line, which is a significant challenge in treating brain cancer. Using a green synthesis method, we created MgS NPs and tested their effects in cultured cells.
When applied at various doses, we observed that 75 µg/mL MgS NPs reduced cancer cell viability by nearly half. The treatment also increased oxidant levels in the cells, aligning with our findings from cytotoxicity tests. Overall, it appears that MgS NPs effectively hinder the growth of neuroblastoma cells.
When applied at various doses, we observed that 75 µg/mL MgS NPs reduced cancer cell viability by nearly half. The treatment also increased oxidant levels in the cells, aligning with our findings from cytotoxicity tests. Overall, it appears that MgS NPs effectively hinder the growth of neuroblastoma cells.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Overall wellbeing
The benefits of calcium and magnesium for health are immense! They ensure proper brain function, strengthen bones, improve sleep quality, lower blood pressure, and support the nervous system among others. I've noticed improvements in my teeth and nails, as well as a decrease in impulsive behaviour, leading to greater calmness in various situations. This dietary supplement truly works! In comparison with others, it offers an excellent price-to-quality ratio and suitable dosages. I wish everyone good health and longevity!
6.8
Cognitive clarity
This supplement has significantly improved my PMDD! It's a fantastic deal, providing many pills for a reasonable price. It has enhanced my sleep and reduced the brain fog I experience during my luteal phase, a time when studies suggest calcium levels are lower.
9
Mood enhancement
I found that it keeps my nervous system in order while also benefiting my nails and bones during breastfeeding. This issue had been with me for about a year, but I finally decided to take action when my daughter was six months old. After four months of use, I've objectively seen improvements. My leg cramps, often caused by a calcium-magnesium deficiency, vanished after the first month. Despite spending nine months at home with my child—known to be a challenging time—my nerves remain calm. I believe this is largely due to the support from the supplement. I've not experienced any issues with my teeth or nails, which many nursing mothers encounter. I attribute this to the benefits of the supplement.
Frequently Asked Questions
6.8
Cognitive clarity
This supplement has significantly improved my PMDD! It's a fantastic deal, providing many pills for a reasonable price. It has enhanced my sleep and reduced the brain fog I experience during my luteal phase, a time when studies suggest calcium levels are lower.
9
Mood enhancement
I found that it keeps my nervous system in order while also benefiting my nails and bones during breastfeeding. This issue had been with me for about a year, but I finally decided to take action when my daughter was six months old. After four months of use, I've objectively seen improvements. My leg cramps, often caused by a calcium-magnesium deficiency, vanished after the first month. Despite spending nine months at home with my child—known to be a challenging time—my nerves remain calm. I believe this is largely due to the support from the supplement. I've not experienced any issues with my teeth or nails, which many nursing mothers encounter. I attribute this to the benefits of the supplement.
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
References
- Sun S, Qian S, Wang R, Zhao M, Li R, et al. Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming. Sci Transl Med. 2025;17:eado0020. doi:10.1126/scitranslmed.ado0020
- Dube CJ, Lai M, Zhang Y, Saha S, Yener U, et al. T-type calcium channels regulate medulloblastoma and can be targeted for therapy. J Neurooncol. 2025. doi:10.1007/s11060-025-04967-5
- Li S, Li W, Miao Y, Gao M, Jia Y, et al. Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth. Sci Transl Med. 2024;16:eadn6763. doi:10.1126/scitranslmed.adn6763
- Nalci OB, Nadaroglu H, Genc S, Hacimuftuoglu A, Alayli A. The effects of MgS nanoparticles-Cisplatin-bio-conjugate on SH-SY5Y neuroblastoma cell line. Mol Biol Rep. 2020;47:9715. doi:10.1007/s11033-020-05987-2
- Zappia F, Verzicco I, Simoni R, Ferrari M, Coghi P, et al. Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment. Acta Biomed. 2020;91:365. doi:10.23750/abm.v91i2.8685
- Mirrahimi B, Mortazavi A, Nouri M, Ketabchi E, Amirjamshidi A, et al. Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial. Acta Neurochir (Wien). 2015;157:985. doi:10.1007/s00701-015-2376-x
